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No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels
- Scott, Robert A (author)
- Chu, Audrey Y (author)
- Grarup, Niels (author)
- show more...
- Manning, Alisa K (author)
- Hivert, Marie-France (author)
- Tönjes, Anke (author)
- Yesupriya, Ajay (author)
- Barnes, Daniel (author)
- Bouatia-Naji, Nabila (author)
- Glazer, Nicole L (author)
- Jackson, Anne U (author)
- Kutalik, Zoltán (author)
- Lagou, Vasiliki (author)
- Marek, Diana (author)
- Rasmussen-Torvik, Laura J (author)
- Stringham, Heather M (author)
- Tanaka, Toshiko (author)
- Aadahl, Mette (author)
- Arking, Dan E (author)
- Bergmann, Sven (author)
- Boerwinkle, Eric (author)
- Bonnycastle, Lori L (author)
- Bornstein, Stefan R (author)
- Brunner, Eric (author)
- Bumpstead, Suzannah J (author)
- Brage, Soren (author)
- Carlson, Olga D (author)
- Chen, Han (author)
- Chen, Yii-Der Ida (author)
- Chines, Peter S (author)
- Collins, Francis S (author)
- Couper, David J (author)
- Dennison, Elaine M (author)
- Dowling, Nicole F (author)
- Egan, Josephine S (author)
- Ekelund, Ulf (author)
- Erdos, Michael R (author)
- Forouhi, Nita G (author)
- Fox, Caroline S (author)
- Goodarzi, Mark O (author)
- Grässler, Jürgen (author)
- Gustafsson, Stefan (author)
- Hansen, Torben (author)
- Hingorani, Aroon (author)
- Holloway, John W (author)
- Hu, Frank B (author)
- Isomaa, Bo (author)
- Jameson, Karen A (author)
- Jørgensen, Torben (author)
- Kivimaki, Mika (author)
- Kovacs, Peter (author)
- Kumari, Meena (author)
- Kuusisto, Johanna (author)
- Laakso, Markku (author)
- Lecoeur, Cécile (author)
- Lévy-Marchal, Claire (author)
- Li, Guo (author)
- Loos, Ruth J F (author)
- Marmot, Michael (author)
- Marques-Vidal, Pedro (author)
- Morken, Mario A (author)
- Müller, Gabriele (author)
- North, Kari E (author)
- Pankow, James S (author)
- Payne, Felicity (author)
- Prokopenko, Inga (author)
- Psaty, Bruce M (author)
- Rice, Ken (author)
- Rotter, Jerome I (author)
- Rybin, Denis (author)
- Sandholt, Camilla H (author)
- Sayer, Avan A (author)
- Shrader, Peter (author)
- Schwarz, Peter E H (author)
- Siscovick, David S (author)
- Stancáková, Alena (author)
- Stumvoll, Michael (author)
- Teslovich, Tanya M (author)
- Waeber, Gérard (author)
- Williams, Gordon H (author)
- Witte, Daniel R (author)
- Wood, Andrew R (author)
- Xie, Weijia (author)
- Boehnke, Michael (author)
- Cooper, Cyrus (author)
- Ferrucci, Luigi (author)
- Froguel, Philippe (author)
- Kao, W H Linda (author)
- Vollenweider, Peter (author)
- Walker, Mark (author)
- Watanabe, Richard M (author)
- Pedersen, Oluf (author)
- Meigs, James B (author)
- Barroso, Inês (author)
- Florez, Jose C (author)
- Dupuis, Josée (author)
- Wareham, Nicholas J (author)
- Langenberg, Claudia (author)
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- (creator_code:org_t)
- 2012-04-13
- 2012
- English.
- In: Diabetes. - Alexandria, VA : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 61:5, s. 1291-1296
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Gene-lifestyle interactions have been suggested to contribute to the development of type 2 diabetes. Glucose levels 2 h after a standard 75-g glucose challenge are used to diagnose diabetes and are associated with both genetic and lifestyle factors. However, whether these factors interact to determine 2-h glucose levels is unknown. We meta-analyzed single nucleotide polymorphism (SNP) × BMI and SNP × physical activity (PA) interaction regression models for five SNPs previously associated with 2-h glucose levels from up to 22 studies comprising 54,884 individuals without diabetes. PA levels were dichotomized, with individuals below the first quintile classified as inactive (20%) and the remainder as active (80%). BMI was considered a continuous trait. Inactive individuals had higher 2-h glucose levels than active individuals (β = 0.22 mmol/L [95% CI 0.13-0.31], P = 1.63 × 10(-6)). All SNPs were associated with 2-h glucose (β = 0.06-0.12 mmol/allele, P ≤ 1.53 × 10(-7)), but no significant interactions were found with PA (P > 0.18) or BMI (P ≥ 0.04). In this large study of gene-lifestyle interaction, we observed no interactions between genetic and lifestyle factors, both of which were associated with 2-h glucose. It is perhaps unlikely that top loci from genome-wide association studies will exhibit strong subgroup-specific effects, and may not, therefore, make the best candidates for the study of interactions.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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- ref (subject category)
- art (subject category)
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- By the author/editor
- Scott, Robert A
- Chu, Audrey Y
- Grarup, Niels
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- Marques-Vidal, P ...
- Morken, Mario A
- Müller, Gabriele
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- Psaty, Bruce M
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- Teslovich, Tanya ...
- Waeber, Gérard
- Williams, Gordon ...
- Witte, Daniel R
- Wood, Andrew R
- Xie, Weijia
- Boehnke, Michael
- Cooper, Cyrus
- Ferrucci, Luigi
- Froguel, Philipp ...
- Groop, Leif
- Kao, W H Linda
- Vollenweider, Pe ...
- Walker, Mark
- Watanabe, Richar ...
- Pedersen, Oluf
- Meigs, James B
- Ingelsson, Erik, ...
- Barroso, Inês
- Florez, Jose C
- Franks, Paul
- Dupuis, Josée
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- Langenberg, Clau ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Endocrinology an ...
- Articles in the publication
- Diabetes
- By the university
- Uppsala University
- Lund University
- Umeå University
- Karolinska Institutet
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